10‘-Hydroxyusambarensine, a New Antimalarial Bisindole Alkaloid from the Roots of Strychnos usambarensis
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منابع مشابه
Leucoridines A-D, cytotoxic Strychnos-Strychnos bisindole alkaloids from Leuconotis.
Four new bisindole alkaloids of the Strychnos-Strychnos type, leucoridines A-D (1-4), were isolated from the stem-bark extract of Leuconotis griffithii. Alkaloids 1-4 showed moderate cytotoxicity against drug-sensitive and vincristine-resistant human KB cells.
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Strychnos usambarensis Gilg (Loganiaceae) is one of thé three most widely distributed African species of Strychnos L. In East and South Africa thé plant grows as a small tree 3-15 m in height. In several other localities in East Africa, as well as in Zaïre, Congo, and West Africa, it is found as a climber up to 70 m long (1). The only other morphological différence between thé two forms is thé ...
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Isostrychnopentamine (ISP) is an indolomonoterpenic alkaloid that is present in the leaves of Strychnos usambarensis, a well known African shrub or little tree. The roots contain quaternary alkaloids, which are used to make a curare-like arrow poison. However, tertiary alkaloids isolated from the same plant possess cytotoxic activities against mammalian cells and protozoa. The effect of ISP has...
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A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by means of spectroscopic data interpretation. Compound 2 was highly active in vitro and compound 1 moderately active against four strains of Plasmodium falciparum. Strychnogucine B (2) was more activ...
متن کاملMelosuavines A-H, cytotoxic bisindole alkaloid derivatives from Melodinus suaveolens.
Eight new bisindole alkaloids, melosuavines A-C (1-3), having an aspidosperma-scandine linkage, melosuavines D-F (4-6), possessing an aspidosperma-aspidosperma skeleton, and melosuavines G and H (7 and 8) of the aspidosperma-venalatonine type, tenuicausine (9), and melodinine J (10) were isolated from the twigs and leaves of Melodinus suaveolens. The structures of 1-8 were elucidated by extensi...
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ژورنال
عنوان ژورنال: Journal of Natural Products
سال: 1999
ISSN: 0163-3864,1520-6025
DOI: 10.1021/np980375m